Valproate, barbiluraies, benzodiazeplnes, baclofen. 2. Membrane stabilizer action - Phenytoln, carbamazepine

of GABA-medaied CMS Inhibition - Valproate, barbiluraies, benzodiazeplnes, baclofen. 2. Membrane stabilizer action - Phenytoln, carbamazepine. Valproate may precipitate phenytoin toxicity (even in absence of raised serum level) due to plasma protein deplacemeni Spinal cord compression - of cord below site of compression from pressure on ascending longitudinal spinal veins 3 Ischemia from Mechanism of .symptoms and signs -1 Direct pressure interfering with conduction in the roots and cord itself. 2. Oedema compression ol spinal arteries Clinical manifestations of lesions in different parts of extrapyrarridal system - Putamen • Athetosis Caudate nucleus - Chorea. Subthalamic nucleus -Hemiballismus. Globus pallidus an Intermittent claudcation - When infernal iliac artery is affected alone, clauofcation in glutens maximus on walking may be The only symptom Diagnostic signs - Patient lies prone and his hip is extended passively, this causes no pain. He is then asked to keep the leg extended for a minute. this brings on the claudication. Spinal claudcatian - Pins and needles in both lower limbs on walking a certain dsiance. All arteries of the lower limbs patent on examination Cause Is intraspinal ischemia of the nerve-roots compressed by a disc lesion or Involved in arachnoidits. 10. Dissecting aneurysm - A rare cause of sciatica Is a slowly expanding aneurysm at the bifurcation of aorta compressing 3rd and 4th LNs. causing local pain and accompanied by paraesthesia and weakness in left lower limb. Severe backache Aortography diagnostic. Management